....Of these, 1,001 (CEU) and 669 (YRI) were validated by re-sequencing the cell line DNA. When these were tested for segregation to offspring (CEU) or in non-clonal DNA from whole blood (YRI), only 49 CEU and 35 YRI candidates were confirmed as true germline mutations.
....
We infer that the remaining vast majority (952 CEU and 634 YRI) of the validated variants were somatic or cell line mutations. The greater number of these validated non-germline mutations in the CEU cell line perhaps reflects the greater age of the CEU cell culture.
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timeasmymeasure
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Date: 2010-11-01 05:02 pm (UTC)....
We infer that the remaining vast majority (952 CEU and 634 YRI) of the validated variants were somatic or cell line mutations. The greater number of these validated non-germline mutations in the CEU cell line perhaps reflects the greater age of the CEU cell culture.